abstract：:The activity of the bimodal fluorescent protein (bmFP) (lambda max, 488 and 517 nm) in the in vitro luciferase reaction has been studied. The bmFP that is produced by Photobacterium phosphoreum strain bmFP is a dimer of two homologous subunits binding four riboflavin 5'-phosphate (FMN)-myristate chromophores. The addi...

journal_title：Photochemistry and photobiology

authors： Karatani H,Konaka T

更新日期：2000-02-01 00:00:00

abstract：:The excited-state intramolecular H-atom transfer reactions of hypocrellins B and A are compared by using time-resolved absorption and fluorescence upconversion techniques. The hypocrellin B photophysics are well described by a simple model involving one ground-state species and excited-state forward and reverse H-atom...

journal_title：Photochemistry and photobiology

authors： Datta A,Smirnov AV,Wen J,Chumanov G,Petrich JW

更新日期：2000-02-01 00:00:00

abstract：:Cumulative and intermittent sun exposure are risk factors for skin cancer, highlighting the need to monitor exposure during childhood. There is currently very little available information concerning the accuracy of self-reported levels of sun exposure, particularly for very young children. In this study, UV radiation ...

journal_title：Photochemistry and photobiology

authors： O'Riordan DL,Stanton WR,Eyeson-Annan M,Gies P,Roy C

更新日期：2000-01-01 00:00:00

abstract：:Catalases are oxidized by singlet oxygen giving rise to more acidic conformers detected in zymograms after electrophoresis in polyacrylamide gels. This shift in catalase mobility can be indicative of singlet oxygen production in vivo. Catalase from human cells, as from many organisms, is susceptible to in vitro modifi...

journal_title：Photochemistry and photobiology

authors： Lledías F,Hansberg W

更新日期：1999-12-01 00:00:00

abstract：:An open three-compartment pharmacokinetic model was applied to the in vivo quantitative structure-activity relationship (QSAR) data of a homologous series of pyropheophorbide photosensitizers for photodynamic therapy (PDT). The physical model was a lipid compartment sandwiched between two identical aqueous compartment...

journal_title：Photochemistry and photobiology

authors： Potter WR,Henderson BW,Bellnier DA,Pandey RK,Vaughan LA,Weishaupt KR,Dougherty TJ

更新日期：1999-11-01 00:00:00

abstract：:The mechanism of caspase-3-dependent apoptosis induced by photodynamic therapy (PDT) of cultured Chinese hamster V79 cells with pheophorbide a (PPa) was investigated. The PPa-PDT induced rapid apoptosis within 30 min after irradiation of cells. This apoptosis was inhibited by the 1O2 quencher N3- and caspase-3 inhibit...

journal_title：Photochemistry and photobiology

authors： Inanami O,Yoshito A,Takahashi K,Hiraoka W,Kuwabara M

更新日期：1999-10-01 00:00:00

abstract：:Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and, after being taken up by colon cancer cells (HCT-116 cells), was localized in cytoplasmic and internal membranes but not in mitochondria. The APP-mediated photo...

journal_title：Photochemistry and photobiology

authors： Matroule JY,Hellin AC,Morlière P,Fabiano AS,Santus R,Merville MP,Piette J

更新日期：1999-10-01 00:00:00

abstract：:The incidence of skin cancer is increasing rapidly, particularly in the Caucasian population. Epidemiological and experimental studies demonstrated that ultraviolet radiation (UVR) is the primary cause for the increasing incidence of skin cancer. It is well known that UV irradiation induces DNA damage. If the damage i...

journal_title：Photochemistry and photobiology

authors： Bush JA,Ho VC,Mitchell DL,Tron VA,Li G

更新日期：1999-09-01 00:00:00

abstract：:An ongoing study in our laboratories is to examine the relationship of DNA repair defects to human cancer. Our underlying hypothesis has been that human tumors may arise that lack interesting DNA repair pathways if these pathways are important in preventing cancer. In this study, we found that the UV-irradiated adenov...

journal_title：Photochemistry and photobiology

authors： Day RS 3rd,Rasouli-Nia A,Meservy J,Lari SU,Dobler K,Tsunoda S,Miyakoshi J,Takebe H,Murray D

更新日期：1999-08-01 00:00:00

abstract：:The energetic characteristics of selected reaction steps in the bacterial luciferase-catalyzed luminescence reaction were examined by computation using the MNDO-PM3 method. Specifically, a three-step model was proposed to account for the reaction between oxygen and reduced riboflavin 5'-phosphate (1,5H2-FMN) to genera...

journal_title：Photochemistry and photobiology

authors： Wada N,Sugimoto T,Watanabe H,Tu SC

更新日期：1999-07-01 00:00:00

abstract：:The interaction of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) and hyperthermia is not well understood. In the present study, significant enhancement of tumor damage was observed after simultaneous application of ALA-PDT and IR-induced hyperthermia using a broad-band incoherent light source. One hour a...

journal_title：Photochemistry and photobiology

authors： Orenstein A,Kostenich G,Kopolovic Y,Babushkina T,Malik Z

更新日期：1999-06-01 00:00:00

abstract：:Analysis of phosphorescence lifetimes using the Stern-Volmer equation is a reliable means of determining quencher concentration for a uniform sample. Methods of analysis for heterogeneous systems are based on the assumption that the excitation is produced by a momentary flash. This condition is an idealization because...

journal_title：Photochemistry and photobiology

authors： Golub AS,Popel AS,Zheng L,Pittman RN

更新日期：1999-06-01 00:00:00

abstract：:Phage T7 can be used as a biological UV dosimeter. Its reading is proportional to the inactivation rate expressed in HT7 units. To understand the influence of phage proteins on the formation of DNA UV photoproducts, cyclobutane pyrimidine dimers (CPD) and (6-4)photoproducts ((6-4)PD) were determined in T7 DNA exposed ...

journal_title：Photochemistry and photobiology

authors： Fekete A,Vink AA,Gaspar S,Modos K,Berces A,Ronto G,Roza L

更新日期：1999-05-01 00:00:00

abstract：:The temperature dependence of the uptake phase of 5-aminolevulinic acid (ALA) and the following production phase of protoporphyrin IX (PpIX) in normal mouse skin was investigated. A cream containing 20% ALA was topically applied on the skin for 10 min. The amount of ALA-induced PpIX was evaluated by measuring the fluo...

journal_title：Photochemistry and photobiology

authors： Juzenas P,Sørensen R,Iani V,Moan J

更新日期：1999-04-01 00:00:00

abstract：:The dependence of autofluorescence properties on the metabolic and functional engagement and on the transformation condition was studied on single cells. Normal Galliera rat fibroblasts at low subculture passage (cell strain), at high subculture passage (stabilized cell line), and transformed cell line derived from a ...

journal_title：Photochemistry and photobiology

authors： Croce AC,Spano A,Locatelli D,Barni S,Sciola L,Bottiroli G

更新日期：1999-03-01 00:00:00

abstract：:Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring hormone with a structural resemblance to tryptophan. Its fluorescence is solvent dependent and strongly quenched in the presence of oxygen. Fluorescence quenching in aqueous and organic solutions have been studied in the presence of different quenchers....

journal_title：Photochemistry and photobiology

authors： Rath MC,Mahal HS,Mukherjee T

更新日期：1999-03-01 00:00:00

abstract：:Identification of natural products capable of affording protection against UVB radiation-induced inflammatory responses and generation of oxidative stress may have important human health implications. The UVB exposure-induced skin injury and oxidative stress has been associated with a variety of skin disease condition...

journal_title：Photochemistry and photobiology

authors： Katiyar SK,Matsui MS,Elmets CA,Mukhtar H

更新日期：1999-02-01 00:00:00

abstract：:Abstract- Time-resolved transmittance was used to extract in vivo optical properties of leaves of green plants experimentally. In time-resolved transmittance measurements an ultrashort light pulse is directed onto the surface of the object and the transmitted light is measured with a time resolution in the range of pi...

journal_title：Photochemistry and photobiology

authors： Johansson J,Berg R,Pifferi A,Svanberg S,Björn LO

更新日期：1999-02-01 00:00:00

abstract：:Photodynamic treatment of promyelocytic K562 cells in the presence of a monoglucosylporphyrin or hematoporphyrin leads to a sequence of events recognized as hallmarks of apoptosis: a drop in mitochondrial potential, concurrent with a drop in ATP level and a decrease in cell respiration, translocation of phosphatidylse...

journal_title：Photochemistry and photobiology

authors： Carré V,Jayat C,Granet R,Krausz P,Guilloton M

更新日期：1999-01-01 00:00:00

abstract：:The photophysical characteristics of two second-generation PDT photosensitizers, tin ethyl etiopurpurin I (SnET2) and tin octaethylbenzochlorin (SnOEBC), have been measured in homogeneous solution and when bound to bovine serum albumin (BSA). The ground state and triplet state absorption spectra have been characterize...

journal_title：Photochemistry and photobiology

authors： Pogue BW,Redmond RW,Trivedi N,Hasan T

更新日期：1998-12-01 00:00:00

abstract：:The tetraruthenated porphyrin, mu-[meso-5,10,15,20-tetra(pyridyl)porphyrin]tetrakis[bis-(bipyridine) chloride ruthenium(II)] (TRP) is a supramolecular cationic species. The aim of the present investigation was to evaluate the photodynamic properties of TRP and Zn-TRP to damage DNA with emphasis on the mechanistic aspe...

journal_title：Photochemistry and photobiology

authors： Ravanat JL,Cadet J,Araki K,Toma HE,Medeiros MH,Mascio PD

更新日期：1998-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) uses laser light to activate a photosensitizer that has been absorbed preferentially by cancer cells after systemic administration. A phototoxic reaction ensues resulting in cell death and tissue necrosis. Some cells, however, may survive PDT. This study was performed to determine if survivi...

journal_title：Photochemistry and photobiology

authors： Hornung R,Walt H,Crompton NE,Keefe KA,Jentsch B,Perewusnyk G,Haller U,Köchli OR

更新日期：1998-10-01 00:00:00

abstract：:This paper studies the dye-sensitized photooxidation of tyrosine (tyr) and tyr di- and tripeptides (tyr-tyr and tyr-tyr-tyr) mediated by singlet molecular oxygen (O2[1 delta g]) in alkaline media. Photooxidation quantum efficiencies (phi r) were obtained by determining the overall and reactive rate constants of intera...

journal_title：Photochemistry and photobiology

authors： Criado S,Soltermann AT,Marioli JM,García NA

更新日期：1998-10-01 00:00:00

abstract：:Multichromophoric dyes for use in tumor imaging have been synthesized and photophysically characterized. Structurally, these dyes are dyads and triads that consist of one or two carotenoid polyenes covalently attached to hematoporphyrin (HP) or hematoporphyrin dimethyl ester (HPDME) moieties via ester linkages. The gr...

journal_title：Photochemistry and photobiology

authors： Tatman D,Liddell PA,Moore TA,Gust D,Moore AL

更新日期：1998-10-01 00:00:00

abstract：:Conventional brain-imaging modalities may be limited by high cost, difficulty of bedside use, noncontinuous operation, invasiveness or an inability to obtain measurements of tissue function, such as oxygenation during stroke. Our goal was to develop a bedside clinical device able to generate continuous, noninvasive, t...

journal_title：Photochemistry and photobiology

authors： Hintz SR,Benaron DA,van Houten JP,Duckworth JL,Liu FW,Spilman SD,Stevenson DK,Cheong WF

更新日期：1998-09-01 00:00:00

abstract：:A solution of iodouracil (0.2 mg/mL) and KI (0.1 M) in 0.23 M borate buffer (pH 7) forms triiodide upon exposure to UVB. In the presence of thyodene, the blue starch-iodine complex is formed, the intensity of which is proportional to the amount of UVB exposure. Studies were conducted using either a sunlamp or solar ir...

journal_title：Photochemistry and photobiology

authors： Rahn R,Lee MA

更新日期：1998-08-01 00:00:00

abstract：:The fluorescent pH probe carboxy-seminaphtorhodafluor-1 (C-Snarf-1) has been used for laser microspectro-fluorometric assays of intracellular pH in 3T3 mouse fibroblasts treated with hypocrellin A. These results are compared to those previously obtained with the structurally related hydroxylated polycyclic quinone, hy...

journal_title：Photochemistry and photobiology

authors： Chaloupka R,Sureau F,Kocisova E,Petrich JW

更新日期：1998-07-01 00:00:00

abstract：:Phototherapy with broadband UVB is an effective treatment for inflammatory dermatoses. A newly developed fluorescent UVB lamp (Philips TL01) that emits a narrowband UVB around 311 nm was shown to be superior for the phototherapy of psoriasis. In order to contribute to the knowledge about the carcinogenic potential of ...

journal_title：Photochemistry and photobiology

authors： Tzung TY,Rünger TM

更新日期：1998-06-01 00:00:00

abstract：:Lymphocytes treated with delta-aminolevulinic acid (ALA) can accumulate the photoactive, fluorescent heme precursor, protoporphyrin IX (PpIX). With visible light illumination, PpIX can be used in photodynamic therapy (ALA-PDT) to kill or functionally alter cells. The aim of this study was to characterize the effects o...

journal_title：Photochemistry and photobiology

authors： Hryhorenko EA,Rittenhouse-Diakun K,Harvey NS,Morgan J,Stewart CC,Oseroff AR

更新日期：1998-05-01 00:00:00

abstract：:Photodynamic therapy (PDT), carried out at low fluence rates, may enhance tumor response as well as affect treatment selectivity. We have studied the effects of fluence rate on the response of the murine radiation-induced fibrosarcoma (RIF) to PDT using Photofrin (5 mg/kg). Tumor response was tested over a large range...

journal_title：Photochemistry and photobiology

authors： Sitnik TM,Henderson BW

更新日期：1998-04-01 00:00:00

abstract：:Targeted mutagenesis and gene knock-out can be mediated by triple helix-forming oligonucleotides (TFO) linked to mutagenic agents, such as psoralen. However, this strategy is limited by the availability of homopurine/homopyrimidine stretches at or near the target site because such sequences are required for high-affin...

journal_title：Photochemistry and photobiology

authors： Raha M,Lacroix L,Glazer PM

更新日期：1998-03-01 00:00:00

abstract：:In this study, we investigated whether the spectrum of p53 mutations in skin tumors induced in hairless SKH-hr1 mice by a solar simulator (290-400 nm) are similar to those found in skin tumors induced in C3H mice by UV radiation from unfiltered (250-400 nm) and Kodacel-filtered (290-400 nm) FS40 sunlamps. Analysis of ...

journal_title：Photochemistry and photobiology

authors： Ananthaswamy HN,Fourtanier A,Evans RL,Tison S,Medaisko C,Ullrich SE,Kripke ML

更新日期：1998-02-01 00:00:00

abstract：:Topical 6,4,4'-trimethylangelicin (TMA) plus UVA was used to induce intense epidermal pigmentation in inbred HRA.HRII-c/+/Skh hairless pigmented mice over a 13 day period. Subsequent UVB/UVA exposure was used to assess the photoprotective properties of this tan using skin tumors as an endpoint. Comparisons were always...

journal_title：Photochemistry and photobiology

authors： Kipp C,Lewis EJ,Young AR

更新日期：1998-01-01 00:00:00

abstract：:Near-infrared spectroscopy has been used to quantify the composition of healthy female breast tissue in vivo. By collecting transillumination spectra in the wavelength range 680-1100 nm at 7-9 positions on the breasts of five female volunteers, an attempt was made to quantify the intra- and intersubject variability of...

journal_title：Photochemistry and photobiology

authors： Quaresima V,Matcher SJ,Ferrari M

更新日期：1998-01-01 00:00:00

abstract：:Proton magnetic resonance imaging (MRI) and histological methods were used to evaluate photodynamic therapy (PDT)-induced hemorrhagic necrosis in the murine M1 tumor within 72 h of treatment of male DBA/2 mice. The effects of three photosensitizing drugs were investigated: Photofrin (n = 4), Zn (II) phthalocyanine (n ...

journal_title：Photochemistry and photobiology

authors： Winsborrow BG,Grondey H,Savoie H,Fyfe CA,Dolphin D

更新日期：1997-12-01 00:00:00

abstract：:Absorbance changes were monitored from 250 to 650 nm during the first microsecond after photolysis of detergent suspensions of bovine rhodopsin at 20 degrees C. Global analysis of the resulting data produced difference spectra for bathorhodopsin, BSI and lumirhodopsin which give the change in absorbance of the aromati...

journal_title：Photochemistry and photobiology

authors： Lewis JW,Jäger S,Kliger DS

更新日期：1997-12-01 00:00:00

abstract：:DNA UVB dosimeters, consisting of minidots of dried bacteriophage DNA placed on a UV-transparent polymer film, were analyzed by polymerase chain reactions (PCR). Ultraviolet-B dosimetry obtained with amplification of phage lambda DNA of segments of 1.08 kilobase pairs (kbp) and 2.24 kbp was compared with that obtained...

journal_title：Photochemistry and photobiology

authors： Yoshida H,Regan JD

更新日期：1997-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) with topical application of delta-aminolevulinic acid (ALA) followed by irradiation with visible light (ALA-PDT) is a relatively new and promising experimental treatment of superficial premalignant and malignant skin neoplasms. The purpose of this study was to determine whether ALA-PDT can p...

journal_title：Photochemistry and photobiology

authors： Stender IM,Bech-Thomsen N,Poulsen T,Wulf HC

更新日期：1997-10-01 00:00:00

abstract：:The fluoroquinolone (FQ) antibiotics photosensitize human skin to solar UV radiation and are reported to photosensitize tumor formation in mouse skin. As tumor initiation will not occur without genotoxic insult, we examined the potential of ciprofloxacin, lomefloxacin, fleroxacin, BAYy3118 (a recently developed monofl...

journal_title：Photochemistry and photobiology

authors： Reavy HJ,Traynor NJ,Gibbs NK

更新日期：1997-09-01 00:00:00

abstract：:Syntheses for the new photosensitizers HOSiPcOSi(CH3)2(CH2)3N(CH1)1 or 3(CH3)2, Pc 34 and Pc 25, have been developed and the order of activity of these photosensitizers and the previously reported photosensitizer Pc 4, HOSiPcOSi(CH3)2(CH2)3N(CH3)2, in the dark and with broad-band red light toward Plasmodium falciparum...

journal_title：Photochemistry and photobiology

authors： Zhao XJ,Lustigman S,Li YS,Kenney ME,Ben-Hur E

更新日期：1997-08-01 00:00:00